Exercise for aging people: where to begin, and how to minimize risk while maximizing potential

In this special episode, Peter addresses the common questions about starting or returning to an exercise routine over the age of 50. Individuals in this age group have frequently reached out with questions about whether it’s too late to start exercising and often express concern over a lack of prior training, a fear of injury, or uncertainty about where to begin.


Fat-free mass (FFM) and physical activity level (PAL) throughout life in females (left) and males (right)

Peter delves into the importance of fitness for older adults, examining all four pillars of exercise, and provides practical advice on how to start exercising safely, minimize injury risk, and maximize potential benefits. Although this conversation focuses on people in the “older” age category, it also applies to anyone of any age who is deconditioned and looking to ease into regular exercise.

#307 ‒ Exercise for aging people: where to begin, and how to minimize risk while maximizing potential | Peter Attia, M.D.

Important: Compare the Candidates on Health Care Policy

The general election campaign has commenced, spotlighting President Biden and former President Trump as the presumptive nominees for their respective parties and the currently viable contenders for the presidency. While this is not an election like in the past where health care reform is a central issue being debated, health care is an important issue for voters and Biden and Trump have sharply divergent records and positions. This side-by-side analysis serves as a quick resource for understanding each candidate’s record as president, positions, public statements, and proposed policies. It will be continuously updated as new information and policy details emerge throughout the campaign.

https://www.kff.org/compare-2024-candidates-health-care-policy/

Mounjaro, Zepbound Help Sleep Apnea

A popular obesity drug may help treat a dangerous disorder in which people struggle to breathe while they sleep, a new study finds.

Tirzepatide, the medication in the weight-loss drug Zepbound and also the diabetes treatment Mounjaro, appeared to reduce the severity of sleep apnea along with reducing weight and improving blood pressure and other health measures in patients with obesity who took the drug for a year.

https://apnews.com/article/sleep-apnea-tirzepatide-obesity-cpap-3872cf70f3e3b385fe98f83afaadc91e

Medical Mysteries: A new mother is felled by ferocious back pain

While breastfeeding her new baby, she developed intense, unexplained pain that kept getting worse.

Several days after her parents’ departure Lucido stumbled into the bathroom early one morning and unintentionally sat down hard on the toilet. Instantly she felt a sickening shudder in her lower back followed by the sensation of an electric current shooting up her spine. Intense nausea came next. Worried she might pass out from the pain, Lucido lay on the bathroom floor.

Aimee Lucido with her baby, Lyra

In 2018 Columbia University’s Irving Medical Center had launched a program headed by endocrinologist Adi Cohen to recruit, study and treat women with a rare condition called pregnancy- and lactation-associated osteoporosis (PLO).

A severe form of early-onset osteoporosis — osteoporosis that occurs before age 50 — PLO can occur in the late stages of pregnancy or during breastfeeding when the loss of maternal calcium leads to a temporary decrease in bone mineral density. Unlike postmenopausal osteoporosis, which is common and affects about 10 million Americans, PLO is rare, although no one knows how rare.

Little is known about the condition, which was described more than 70 years ago. Misdiagnosis is common and many doctors have never seen a case.

https://www.washingtonpost.com/health/2024/06/22/pregnancy-backpain-breastfeeding-medical-mysteries/

Daily multi-vitamin may slow dementia

Taking daily multivitamins appears to slow cognitive aging by about 2 years in older adults, three new studies show.

In the latest study, published Thursday in The American Journal of Clinical Nutrition, researchers observed and tested 573 adults 60 and older in person. In the two previous studies, people taking part in the research responded by phone or online. Overall, about 5,000 people took part in the three studies.

The in-person study showed the multivitamin provided a “modest benefit” on global cognition over 2 years, compared to a placebo. Global cognition includes brain activities such as reasoning, attention, and planning. The multivitamin showed “a statistically significant benefit” for episodic memory, but not in executive function and attention, a news release said.

https://www.webmd.com/healthy-aging/news/20240119/multivitamins-slow-cognitive-aging-seniors-study

https://www.amazon.com/Equate-Complete-Multivitamin-Compare-Centrum/dp/B00DPLZG3W

Do we have Alzheimer’s disease all wrong?

“As Science noted in its story on the retracted paper, scientists are still debating whether the amyloid theory is viable. The skeptics cite the fraudulent research and lack of a genuine breakthrough; supporters can point to this new class of drugs including donanemab that have led to some improvement in some patients.”

https://www.vox.com/future-perfect/355108/alzheimers-disease-drug-approval-research-retraction

The US Healthcare System: How Did We Get Here and What Will It Take To Get Out’

Highly Recommended: Excellent must-read slide deck from Professor Richard Wender

What causes multiple sclerosis—and why are women more at risk?

“Around 2.9 million people worldwide—roughly one million in the United States—have multiple sclerosis or MS; Applegate and The Sopranos star Jamie-Lynn Sigler are two of them. In their podcast, the actresses speak candidly about their experiences with the disease.
MS affects the central nervous system, the brain and spinal cord. The immune system attacks sheaths of a material called myelin that surround nerve fibers. Like insulation on wires, myelin protects nerves and helps transmit signals. But when myelin deteriorates, the nerve fibers underneath are exposed. This disrupts the brain’s communication and leaves behind lesions, which can cause a myriad of symptoms as the disease progresses.”

https://www.nationalgeographic.com/science/article/multiple-sclerosis-ms-cause-treatment-ebv

Two Is Better Than One in the Alzheimer’s Market

“Last week, a panel of independent advisers to the FDA unanimously voted in support of Eli Lilly’s donanemab, a competitor in the same class of drugs that target amyloid plaques in the brain. The FDA is expected to decide on whether to approve the drug by the end of the year.

Life expectancies around the world have surged in recent decades, increasingly putting people at risk of dementia. About one in nine seniors has Alzheimer’s disease, the most common cause of the condition, which works out to some seven million Americans.”

https://finance.yahoo.com/news/two-better-one-alzheimer-market-110000384.html

Apple Vision Pro Game Changer for Disabled

The headset is already changing disabled users’ lives.

In her childhood bedroom, Maxine Collard had a PC connected to a cathode-ray tube monitor so massive it bowed her desk into a smile that grew deeper every year. Collard has oculocutaneous albinism, which means that her hair is naturally bleach white, her complexion maximally fair, and she has uncorrectably low visual acuity with limited depth perception. In order to see the screen, she had to crane her neck until her face was two inches from the monitor.

When Collard was in middle school, her mother bought an iMac for the family. Collard spent hours messing around on the new machine, her nose pressed almost to the glass. One day, deep in the computer’s accessibility settings, she discovered that if she held down the control key while spinning the mouse’s scroll wheel, she could instantaneously zoom the entire screen to whatever magnification level she wanted. There was a rudimentary magnifier app on her Windows computer, but she found the interface difficult to use, and the low-res image on the zoomed-in PC screen, she said, was pixelated, hard to read, “disgusting.” Her experience on the iMac, which allowed her to magnify the entire screen into a much clearer image, came as a revelation.

Earlier this year, Collard had a similar aha moment when she tried the Apple Vision Pro for the first time. Some critics of the AVP were skeptical of a device that pressed two high-resolution micro-OLED screens within millimeters of one’s eyes for hours at a time. But to Collard, the ability to (as she put it) “strap an iPad to my face” was instantly appealing.

See Link for more:

https://nymag.com/intelligencer/article/apple-vision-pro-disabled-users.html