How the brain gets rid of its chemical waste through the glymphatics during sleep, via blood vessel oscillations, regulated by norepinephrine. Impeded by Ambien.

• Norepinephrine release from the locus coeruleus drives slow vasomotion in NREM sleep

• Infraslow norepinephrine oscillations control opposing changes in blood and CSF volumes

• Norepinephrine oscillation frequency during NREM sleep predicts glymphatic clearance

• The sleep aid zolpidem suppresses norepinephrine oscillations and glymphatic flow

https://www.cell.com/cell/abstract/S0092-8674(24)01343-6

https://www.science.org/content/article/scientists-uncover-how-brain-washes-itself-during-sleep