Alzheimer’s disease, the most prevalent form of dementia, typically occurs after the age of 65. A significant genetic factor associated with this type of Alzheimer’s at a younger age is a gene called apolipoprotein E (APOE), which comes in three common variations:
APOE e2: This form is the least common and is associated with a reduced risk of Alzheimer’s disease.
APOE e4: More prevalent than e2, this gene variant increases the risk of Alzheimer’s and is linked to a more severe form of the disease.
APOE e3: The most common variant, it does not seem to significantly affect the risk of developing Alzheimer’s.
It’s important to note that genes are not the sole determining factor in Alzheimer’s disease risk.
Each individual inherits one copy of the APOE gene from each parent. Having at least one APOE e4 gene doubles or triples the risk of developing Alzheimer’s disease. Some individuals inherit two APOE e4 genes, one from each parent, which substantially increases the risk, by about eight- to twelvefold.
One of my frequent admonishments to patients is to only eat what God makes (or just avoid anything with a bar code — until a patient reminded me that fruit and vegetables are bar coded 😂)
“A review of research involving almost 10 million people has found a direct association between eating too many ultra-processed foods — those breads, cereals, snacks and frozen meals that have been industrially manufactured with flavors and additives to make them more palatable — and more than 30 health conditions, including heart disease, anxiety and early death.”
Leave it to TikTok to come up with strategies on how to sleep better. I’m told the “sleepy girl mocktail” is the latest recommendation. It’s a concoction of tart cherry juice, magnesium powder and soda water, poured over ice. Cherries are a natural source of melatonin and also contains tryptophan, which combined with magnesium is purported to calm down your nervous system for better rest.
Here’s one recipe for the Sleepy Girl Mocktail (there are many variations.) You’ll need a few ingredients and a large glass. Give it a try and let us know if it works for you in the Comment section.
Fill a glass of your choosing with ice. Next, pour in the ½ cup of cherry juice. Add 1 tablespoon of magnesium powder to the liquid and stir well. Then top it off with your favorite lemon-lime flavored beverage. Some people also add two teaspoons of elderberry syrup.
“They say it takes a village to raise a child. Centered on that concept of communal flourishing, Northwest England’s first intergenerational care village, home to both older people and young children living and learning together, recently celebrated its official opening.
Stimulation, learning, fun—these are activities that are known to delay the progression of dementia, and what better way to add these critical elements of life to a daily regimen than to let a flock of preschoolers do it?”
“Get ready to focus on your brain, because according to the AAN, the era of preventive neurology has arrived. In fact, the academy is hoping that all Americans will be on the healthy brain train by 2050.
“It’s a brain health revolution,” Rost said. “We want to help the public understand that a lifetime of health begins with brain health.”
Focused stimulation for Parkinson’s This phenomenon was first described in the 19th century when Professor Jean-Martin Charcot noticed an improvement in his Parkinson’s patients after a bumpy carriage ride.”
Delaware is 43rd among states in the US with 38% of the population considered obese! For comparison, West Virginia is 50th with 41% obese, and Colorado ranked 1st with 25% obese.
GLP-1 medications semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) are expensive treatment options for obesity, usually $1,000 or more per month (although insurers and PBM’s pay less – I’ve heard around $500 +/-) The State of Delaware is currently blaming the expense of these medications on the increase in cost of the State Employee benefit programs.
Not factored in are the savings from complications of diabetes and hypertension and the reduction in cardiovascular and orthopedic disorders (savings which may take years to show up.)
Presently, Delaware has been spending about $2.5 million a month on these drugs – total health plan spending over the first six months is about $15 million, which would equate to $30 million per year!
Delaware chose to cover the drugs last March and is now reassessing whether to make changes to its coverage policies. The State Employee Benefits Committee, which oversees Delaware’s health care plans for state workers and retirees, will be discussing this issue at upcoming meetings on Feb. 20, March 11 and 25 before making a recommendation to the State. Email the benefits committee at sebc@delaware.gov if you would like to comment.
According to a recent NPR story on Delaware Public Media, drugs like Ozempic can help weight loss, but not without ethical and health concerns.
“North Carolina shouldered the cost of the weight loss drug Wegovy for 2,800 state workers in 2021. Last year, that number shot up to 25,000 totaling $100 million.
Last Thursday, the state decided not to pay for it any longer. Celebrities and people like Elon Musk who can afford $1,000 a month for Ozempic and Wegovy can still get them. However, a nurse in North Carolina told The New York Times that finding Wegovy is like winning the lottery.
These Food and Drug Administration-approved, plant-based injectable drugs were initially developed to treat diabetes, but they also help with obesity. But demand for Ozempic and Wegovy’s weight-loss properties rose so high that diabetics had trouble finding them. There aren’t enough chemicals to keep up with the demand, creating a scarcity.”
“I talk to our dog; I talk to our cats. Mind you that these are not deep conversations, such as the ones I have with my wife. It turns out, however, that the presence of pets in the house can have profound effects on slowing the verbal cognitive decline in older individuals. There is one catch: you have to be living alone.”
“I believe this study underscores something that is all too real about disconnectedness in our modern culture. Loneliness and isolation are significant threats to physical and mental health. Recently, the US Surgeon General issued an advisory on the public health crisis of loneliness, isolation, and lack of connection in our country.1 Primary care clinicians need to be aware of this and ask patients specifically about their social networks and feelings of loneliness.”
Ollie and Maxine
“Reaching out to, and building connections with family, friends, and — importantly — others in our communities who are disconnected, is vitally important to health and well-being. And, in some cases, a household pet can be a big benefit. I tell this to my dog and cats all the time.”
“Sleep has a huge impact on our health. It helps our brains function, protects against heart disease and supports our immune system. And without it we would die.
Although for something so important, we aren’t formally taught how to do it right, says Rebecca Robbins, a sleep scientist at the Brigham and Women’s Hospital and an assistant professor of medicine at Harvard Medical School. “In America, you learn about nutrition or sex ed in school, but never about sleep.”
CNMRI: Neurology, Sleep Medicine, MRI 