Interesting study based on a lot of data from the Migraine Buddy App

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Simultaneous Comparisons of 25 Acute Migraine Medications Based on 10 Million Users’ Self-Reported Records From a Smartphone Application

TL:DR
Medication Effectivenes

Triptans (in order of effectiveness but all close.)

  1. Elettriptan (Relpax – about $50 per Rx)
  2. Zolmitriptan (Zomig $20)
  3. Sumatriptan (Imitrex $15)
  4. Rizatriptan (Maxalt $10)

NSAIDS/OTC’s

  • Diclofenac Potassium 50 mg (Cataflam $15) slightly more effective than Naproxen Sodium 550 mg (Aleve or Anaprox DS $10),  Excedrin or Tylenol
  • Kerotolac 10 mg (Toradol $15) slightly more effective than Diclofenac (Kerotolac may have more side effects than Diclofenac.)

Forest Plot of the Odds Ratios and 95% CI of Medications From Canada (CA), the United Kingdom (UK), and the United States (USA) in Country-Specific Analysis

https://www.neurology.org/doi/full/10.1212/WNL.0000000000207964

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